Pyramid® + Presponse® SQ

Modified Live Vaccine Tutorial

Learn how to properly mix, store, handle and administer Modified Live Vaccine (also en Español)

Why should you use PYRAMID 5 + PRESPONSE SQ?

Cattle producer James Tanner shares a little about his operation and why PYRAMID 5 + PRESPONSE SQ is a good fit for helping to protect calves against respiratory disease.

Vaccinate Calves for Health and Performance

The right vaccine plays a big role in protecting your calves against respiratory disease. Learn why PYRAMID 5 + PRESPONSE SQ is the right choice.

Weaning Vaccinations

Not sure if you should be vaccinating calves against BRD prior to weaning? Here's some information to help you decide.

Respiratory Disease (BRD)

Provide your weaned calves with the protection they need against the major causes of respiratory disease.

Coming soon!

Product Description

The PYRAMID PRESPONSE family of vaccines are single-dose products providing broad coverage of bovine viral diarrhea virus (BVDV) Types 1 and 2, infectious bovine rhinotracheitis (IBR), parainfluenza-3 (PI3), bovine respiratory syncytial virus (BRSV), which are modified live viruses (MLV), and Mannheimia haemolytica with options for various combinations dependent upon product. PYRAMID PRESPONSE delivers enhanced efficacy with the help of the MetaStim® adjuvant system, enhancing the animal’s response to the vaccine for greater protection.

  • Provides broad coverage against BVDV Types 1 and 2, IBR, BRSV, PI3 and Mannheimia haemolytica
  • Available in a variety of different modified live virus (MLV) combinations
  • Meets Beef Quality Assurance (BQA) guidelines for both dosage level and administration route

The Pyramid® + Presponse® SQ Family:


Features and Benefits

  • The PYRAMID PRESPONSE family of vaccines provides broad coverage for BVDV Types 1 and 2, IBR, BRSV, PI3 and Mannheimia haemolytica with only a single dose.  They contain the MetaStim® adjuvant system to enhance the animal’s response for greater protection.
  • PYRAMID PRESPONSE vaccines are available in varying modified live virus product combinations.
  • PYRAMID 3 + PRESPONSE SQ and PYRAMID 5 + PRESPONSE SQ contain both BVDV Type 1 (Singer) and 2 (5912), which are specifically selected for broad BVDV coverage. The flexibility to vaccinate pregnant cows, or calves nursing pregnant cows, if the cows were vacinated pre-breeding according to label instructions with Express® FP vaccine, PYRAMID 5, PYRAMID 10, PYRAMID 3, PYRAMID 3 + PRESPONSE SQ, or PYRAMID 5+ PRESPONSE SQ.

Dosage Information

  • 2 mL administered subcutaneously
  • Annual revaccination required
  • See individual product labels for complete dosage information

Safety Information

  • A small percentage of animals may show transient mild injection site swelling.
  • Do not vaccinate within 21 days before slaughter.
  • Burn container and all unused contents.
  • In case of anaphylactoid reaction, administer epinephrine.
  • Store in the dark at 35 - 45°F (2 - 7°C). Avoid freezing.
  • See individual product labels for details regarding use in pregnant cows or calves nursing pregnant cows.

  • Each darkly colored rectangle represents an interaction between an antibody and the tested virus strain.
  • A high occurrence of interaction indicates a broad range of antigen/antibody interaction for the tested virus strain.
  • Using the two BVDV strains in PYRAMID, this panel demonstrated a wide range of reactive proteins covered by the vaccine — 80 percent of the antibodies reacted.

Product Resources

Contact Information

  • Boehringer Ingelheim Vetmedica, Inc.

    Cattle Division

    3902 Gene Field Road
    St. Joseph, Missouri 64506

    • Phone 866-638-2226
    • Fax 816-326-9167
    • e-mail