Pyramid® + Presponse® SQ – Protect Beef Calves from BVDV with a Modified-Live Virus Vaccine

Early Vaccination for Beef Cattle Health and Performance

Dr. Peggy Thompson, DVM, Boehringer Ingelheim, shares tips on getting the most out of your respiratory vaccination program, including starting early.

BVDV Podcasts

Dr. Chris Chase, DVM, South Dakota State University, explains BVD virus, diagnosis, how it affects cattle and how to protect your animals with management and vaccines.

BVDV Video

Watch out for the most common type of BVD virus in the country, BVDV Type 1b, and make sure your animals are protected with an approved vaccine.

Unique MetaStim® Adjuvant

PYRAMID 5 + PRESPONSE SQ includes a trusted ingredient that helps stimulate a strong immune response and provide the best possible protection.

Why Does BVDV Type 1b Matter?

Boehringer Ingelheim’s Dr. John Davidson, DVM, gives his top five reasons to protect against bovine viral diarrhea virus Type 1b.

The BVDV Type 1b challenge: PYRAMID 5 + PRESPONSE SQ is the solution.

The PYRAMID and PRESPONSE vaccine families protect cattle from respiratory disease by providing broad coverage against the primary viruses and bacteria that contribute to bovine respiratory disease complex. Click on the tabs below to learn more.

Top Reasons to Use
PYRAMID 5 + PRESPONSE SQ:

1) Single-Dose, Modified-Live Virus Vaccine

  • Protects against bovine viral diarrhea virus (BVDV) Type 1, including Type 1b, and Type 2, infectious bovine rhinotracheitis (IBR), parainfluenza 3 (PI3), bovine respiratory syncytial virus (BRSV) and Mannheimia haemolytica.
  • Provides a duration of immunity of at least 217 days against BVDV Type 1b.

2) Broad Protection

  • Specifically labeled to protect against the most common type of BVDV in the country, Type 1b.
  • Contains the Singer BVDV Type 1 and the 5912 BVDV Type 2 strains, which were specifically selected to offer broad antigen/antibody response.

3) Unique METASTIM Adjuvant

  • Helps provide enhanced protection against key virus antigens, experienced during natural challenges and environmental stress.

4) Effective Whole-herd Protection

  • Vaccinate cows with Express® FP to prevent persistently infected calves from being born and spreading BVDV.
  • Use PYRAMID 5 + PRESPONSE SQ in calves nursing pregnant cows properly vaccinated with either PYRAMID or EXPRESS FP vaccines.

Formulations Available:

PYRAMID 5 + PRESPONSE SQ

  • MSDS
  • Label

PYRAMID 3 + PRESPONSE SQ

  • MSDS
  • Label

Dosage Information:

  • 2 mL administered subcutaneously
  • Annual revaccination required
  • See individual product labels for complete dosage information

Safety Information:

  • A small percentage of animals may show transient, mild injection-site swelling.
  • Do not vaccinate within 21 days before slaughter.
  • Burn container and all unused contents.
  • In case of anaphylactoid reaction, administer epinephrine.
  • Store in the dark at 35–45°F (2–7°C); avoid freezing.
  • See individual product labels for details regarding use in pregnant cows or calves nursing pregnant cows.

Features and Benefits of PYRAMID:

The PYRAMID family of modified live virus vaccines are single-dose products providing broad coverage of bovine viral diarrhea virus (BVDV) Types 1 and 2, infectious bovine rhinotracheitis (IBR), parainfluenza 3 (PI ) and bovine respiratory syncytial virus (BRSV).

  • The addition of the unique METASTIM adjuvant helps stimulate a strong immune response; METASTIM is a trusted adjuvant in many Boehringer Ingelheim vaccines that helps provide the best possible protection against key virus antigens, even in the face of natural challenges and environmental stress.
  • Vaccines are available in a variety of different combinations, including 5-way lepto or Lepto pomona-hardjo.
  • Most products in the PYRAMID family contain the Singer BVDV Type 1 and the 5912 BVDV Type 2 strains, which were specifically selected to offer broad antigen/antibody response.
  • Provides effective whole-herd protection in combination with Express® FP.
    • Vaccinate cows with EXPRESS FP to prevent persistently infected calves from being born and spreading the BVD Virus.
    • PYRAMID can be used in calves nursing cows properly vaccinated with either PYRAMID or EXPRESS FP vaccines.

Formulations Available:

PYRAMID 3

  • MSDS
  • Label

PYRAMID 3 LPH

  • MSDS
  • Label

PYRAMID 5

  • MSDS
  • Label

PYRAMID 10

  • MSDS
  • Label

PYRAMID IBR

  • MSDS
  • Label

PYRAMID IBR-LPH

  • MSDS
  • Label

Dosage and Safety Information:

Dosage Information:

  • 2 mL administered subcutaneously
  • Annual revaccination required
  • See individual product labels for complete dosage information

Safety Information:

  • A small percentage of animals may show transient, mild injection-site swelling.
  • Do not vaccinate within 21 days before slaughter.
  • Burn container and all unused contents.
  • In case of anaphylactoid reaction, administer epinephrine.
  • Store in the dark at 35–45°F (2–7°C); avoid freezing.
  • See individual product labels for details regarding use in pregnant cows or calves nursing pregnant cows.

Formulations Available:

PRESPONSE SQ

  • Aids in the reduction of severity of pneumonic pasteurellosis caused by Mannheimia haemolytica.
  • Dosage:
    • 2 mL administered subcutaneously.
    • Healthy cattle three months of age or older should be vaccinated a minimum of 14 days prior to shipping or exposure to stress.
    • Although only a single dose is necessary to confer active immunity, a booster dose is recommended whenever subsequent stress is likely.
  • Safety Information:
    • Store in the dark at 2° to 7°C (35° to 45°F); do not freeze.
    • Shake well; use entire contents when first opened.
    • Do not vaccinate within 21 days before slaughter.
    • Transient injection-site reactions may occur in a small percentage of vaccinates.
    • In case of anaphylactoid reaction, administer epinephrine.

PRESPONSE HM

  • Aids in the prevention of pneumonic pasteurellosis by stimulating immunity to P. multocida and aids in the reduction of respiratory disease due to Mannheimia haemolytica.
  • Dosage:
    • 2 mL administered subcutaneously.
    • Healthy cattle seven months of age or older should be vaccinated a minimum of 21 days prior to shipping or exposure to stress, which may precipitate infectious conditions.
    • Although only a single dose is necessary to confer active immunity, a booster dose is recommended whenever subsequent stress is likely.
  • Safety Information:
    • Store in the dark at 2° to 7°C (35° to 45°F); do not freeze.
    • Shake well; use entire contents when first opened.
    • Do not vaccinate within 21 days before slaughter.
    • Transient injection-site reactions may occur in a small percentage of vaccinates.
    • In case of anaphylactoid reaction, administer epinephrine.

Product Resources

Contact Information

  • Boehringer Ingelheim Animal Health USA Inc.

    Cattle Division

    3239 Satellite Blvd NW,
    Duluth, GA 64506

    • Phone 866-638-2226
    • Fax 816-326-9167
    • e-mail
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Fulton RW, Ridpath JF, Saliki JT, et al. Bovine Viral Diarrhea Virus (BVDV) 1b: Predominant BVDV Subtype In Calves With Respiratory Disease. Can J Vet Res 2002;66(3):181–190.

EXPRESS®, PYRAMID® and PRESPONSE® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc.  All other trademarks are property of their respective owners.
©2019 Boehringer Ingelheim Animal Health USA Inc. All rights reserved. BOV-1836-RESP0119