cephapirin sodium

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Culturing Tips at Your Fingertips

Tools and information for using culture-based mastitis treatment on your farm.
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See How ToDAY® Can Benefit Your Operation

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Product Description 

An antibiotic mastitis treatment providing bactericidal activity against Gram-positive and Gram-negative bacteria in lactating dairy cows.

  • Each 10 mL disposable, ready-to-use syringe contains the active ingredient cephapirin sodium
  • Provides control against mastitis-causing pathogens – including penicillin-resistant Staph aureus and Strep agalactiae
  • Easy two-tube treatment given 12 hours apart
  • Opti-Sert® applicator tip aids in full or partial insertion


  • Pail containing 144 x 10 mL syringes and 144 convenient single-use alcohol pads.
  • Cartons containing 12 x 10 mL syringes with 12 convenient single-use alcohol pads.

Features & Benefits

Intramammary mastitis treatment of Gram-positive infections is widely reported as beneficial,4 so those infections should be the focus of treatment.1

Stop wasting time, milk and money treating Gram-negative and no-growth cases of mastitis. Culture your milk to determine which of those cases will self-treat and which are Gram-positive.

Choosing a short-duration treatment protocol allows you to treat mastitis with less antibiotics than a five- or eight-day protocol without sacrificing efficacy.

Using two tubes instead of five is better for you, better for the cow, and better for consumers.


Requires less labor, costs your business less money.


Fewer days of antibiotic treatment, less time spent in the hospital pen.


Antibiotics used judiciously increases consumer confidence.

Two tubes of ToDAY® given according to the label will result in 60 fewer hours of milk withhold time as compared to using five tubes of SPECTRAMAST LC,  therefore reducing time cows spend in the hospital pen by more than 35 percent. Using ToDAY in combination with a culture-based protocol can save a 1,000-cow dairy over $30,000 annually.3


Infuse a 10 mL syringe (200 mg of cephapirin activity per syringe) once the quarter has been completely milked out. Repeat once only in 12 hours. For lactating cows only. Read and follow label directions.

Safety Information:

Milk that has been taken from animals during treatment and for 96 hours after the last treatment must not be used for food. Treated animals must not be slaughtered for food until 4 days after the last treatment. Administration of more than the prescribed dose may lead to residue of antibiotic in milk longer than 96 hours.

ToDAY should be administered with caution to subjects that have demonstrated some form of allergy, particularly to penicillin. Such reactions are rare; however, should they occur, consult your veterinarian.

1 Keefe G, MacDonald K, Cameron M. On-farm culture use experience and impact on antimicrobial use. University of Prince Edward Island, Charlottetown, PE, Canada.

2 Schukken YH, Zurakowski MJ, Rauch BJ, et al. Non-inferiority trial comparing a first-generation cephalosporin with a third-generation cephalosporin in the treatment of non-severe clinical mastitis in dairy cows. J Dairy Sci 2013;96(10):6763-6774.

Nydam D, Virkler P, Capel M, et al. Pathogen-based treatment decisions for clinical mastitis, in Proceedings. NMC Regional Meeting 2015;1–4.

4 Hess JL, Neuder LM, Sears PM. Rethinking clinical mastitis therapy, in Proceedings. 42nd Annual Meeting of the National Mastitis Council 2003:372-373.

Product Resources

Contact Information

  • Boehringer Ingelheim Vetmedica, Inc.

    Cattle Division

    3239 Satellite Blvd NW,
    Duluth, GA 64506

    • Phone 866-638-2226
    • Fax 816-326-9167
    • e-mail

Technical Bulletins

  • A Non-Inferiority Trial Comparing a First Generation Cephalosporin with a Third-Generation Cephalosporin in the Treatment of Non-Severe Clinical Mastitis in Dairy Cows.

  • Minimum Inhibitory Concentrations (MIC) for Cephalosporin Compounds on Their Active Metabolites for Selected Mastitis Pathogens.

  • Randomized Non-Inferiority Clinical Trial Evaluating Three Commercial Dry Cow Mastitis Preparations.