Cystorelin® (gonadorelin) –GnRH for use in reproductive programs in cows and heifers.

Synchronization Claim

Efficient reproduction is vital to the success of any beef or dairy operation, and not something that should be left to chance. Read more about the use of CYSTORELIN and Synchsure® together.

Product Guide

Download the CYSTORELIN and SYNCHSURE detailer to learn more about the products and how to use them in a synchronization program.

Product Description

CYSTORELIN is indicated for the treatment of ovarian follicular cysts in dairy cattle. Ovarian cysts are non-ovulated follicles with incomplete luteinization which result in nymphomania or irregular estrus.

Historically, cystic ovaries have responded to an exogenous source of luteinizing hormone (LH) such as human chorionic gonadotropin. CYSTORELIN initiates release of endogenous LH to cause ovulation and luteinization.

CYSTORELIN was the first-selling GnRH productapproved by the FDA for treatment of cystic ovaries in cattle. CYSTORELIN is labeled for use in combination with SYNCHSURE to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy cows and beef cows.

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Features and Benefits


  • CYSTORELIN is available in a 10-bottle carton with 15 doses per bottle. That gives you more doses in one bottle than any other GnRH. A flexible 5-dose bottle is also available.


  • In a study,1 CYSTORELIN induced the highest peak and highest average LH responses as well as the highest ovulatory response of 95% compared to Fertagyl® (gonadorelin) and Factrel® (gonadorelin hydrochloride).


  • CYSTORELIN has no milk withholding and no meat withdrawal.
  • Once opened, CYSTORELIN has a 6-month shelf life, and is stored at or below 77°F.

Top Reasons for using CYSTORELIN and SYNCHSURE in a Synchronization Program

1) CYSTORELIN and SYNCHSURE should be the go-to combination for reproductive efficiency in cows and heifers.

  • Efficient reproduction is vital to the success of any operation, so it’s not something that should be left to chance. CYSTORELIN and SYNCHSURE can help you take the guesswork out of herd management to meet your reproduction goals.

2) Help your herd conceive and calve on schedule.

  • When used in combination, CYSTORELIN and SYNCHSURE can provide:
    • Shortened time to first service
    • Increased estrus detection efficiency
    • Improved first-service conception rate

3) Reduce your days open and save money.

  • A missed heat cycle can cost $29, and a missed pregnancy can cost
    $450.2,3 Don’t let poor reproductive performance and extended lactations steal from your bottom line. Proper use of CYSTORELIN and SYNCHSURE can increase your herd pregnancy rate, therefore reducing your days open to save you money.

4) Customized syringes.

  • Customized syringes are available for CYSTORELIN and SYNCHSURE with their respective product logos to allow for ease of administration and to prevent confusion of products.

5) Flexible and easy to use.

  • CYSTORELIN is available in a 10-bottle carton with 15 doses per bottle, as well as the flexibility of a 5-dose bottle. CYSTORELIN has no milk withholding and no meat withdrawal. Once opened, it has a 6-month shelf life when stored at or above 77°F.
  • SYNCHSURE can be used in a single-or two-dose protocol and is available in a single 100 mL bottle, 8-pack 100 mL bottles or a case of 64 100 mL bottles. Once opened, SYNCHSURE has a 6-month shelf life, and no refrigeration is ever required.

CYSTORELIN Dosage and Safety

Dosage Information

  • 100 mcg (2 mL) per cow via intravenous or intramuscular injection.
  • Store at or below 77°F (25°C). Brief excursions to 86°F (30°C) are permitted.

Safety Information


IMPORTANT SAFETY INFORMATION FOR SYNCHSURE: FOR ANIMAL USE ONLY, NOT FOR HUMAN USE.  KEEP OUT OF REACH OF CHILDREN. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages women may be unaware of their pregnancies. Synchsure® (cloprostenol sodium) is readily absorbed through the skin and may cause abortion and/or bronchospasms: direct contact with the skin should therefore be avoided. Accidental spillage on the skin should be washed off immediately with soap and water.

CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

Product Resources

Contact Information

  • Boehringer Ingelheim Animal Health

    3239 Satellite Blvd
    Duluth, GA 30096

    • Phone 866-638-2226
    • Fax 816-326-9167
    • e-mail


1 Martinez MF, Mapletoft RJ, Kastelic JP, Carruthers T. The effects of 3 gonadorelin products on luteinizing hormone release, ovulation and follicular wave emergence in cattle. Canadian Vet J 2003; 44:125-131.

Meadows C. A spreadsheet-based model demonstrating the nonuniform economic effects of varying reproductive performance in Ohio dairy herds. J Dairy Sci 2005;88:1244-1254.

Fricke PM, et al. Pregnant vs. open: Getting cows pregnant and the money it makes. Proceedings, Western Dairy Management Conference. 2005;49-62.


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