(cloxacillin benzathine)

Get your easy step-by-step guide:


  • Helps prevent pushing harmful surface bacteria into the teat canal
  • Provides the convenience of full or partial insertion
  • Partial insertion of mastitis tubes is proven to reduce new mastitis infections by up to 50 percent1

Product Description

An antibiotic mastitis treatment providing bactericidal activity against Gram-positive bacteria in dry cows.

  • Each 10 mL disposable, ready-to-use syringe contains the active ingredient, cloxacillin benzathine.
  • Provides bactericidal activity against Gram-positive bacteria - Strep agalactiae, penicillin-resistant Staph aureus and non-penicillinase-producing Staph aureus.
  • Convenient zero milk withhold when used 30 days prior to calving.
  • Opti-Sert® applicator tip aids in full or partial insertion.
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.


  • Pail containing 144 x 10 mL syringes and 144 convenient single use alcohol pads.
  • Cartons containing 12 x 10 mL syringes with 12 convenient single use alcohol pads.

Features and Benefits

Think Gram-positive

  • 95 percent of dry cow mastitis is caused by Gram-positive pathogens2
  • DRY-CLOX provides bactericidal activity against Gram-positive bacteria - Strep agalactiae, penicillin-resistant Staph aureus and non-penicillinase-producing Staph aureus.
  • In a study, 98% of the Staph aureus isolates tested were sensitive to cloxacillin benzathine.3

Proven Efficacy

  • In a head to head trial between DRY-CLOX and ceftiofur hydrochloride, there were no statistical differences between the following parameters2:
    • Infections at calving
    • Risk for cure
    • Risk for new infection
    • Risk for clinical mastitis at 100 days in milk
    • Risk for culling
    • DHIA test performance for milk, percent butterfat, percent protein and SCC up to 100 DIM.

Long Lasting Activity With Zero Milk Withhold*

  • A zero milk withhold from dry pen to bulk tank lets your cows go right back to being profitable members of your herd.
  • DRY-CLOX offers the option of a 30-day dry period.

*Zero milk discard period after calving following a 30-day dry cow period.

Dosage Information

At dry off, at least 30 days prior to calving, infuse a 10 mL syringe (500 mg cloxacillin activity per syringe) once each quarter has been completely milked out.

Safety Information:

For use in dry cows only. Do not use within 30 days of calving. Any animal infused with this product must not be slaughtered for food until 30 days after the latest infusion.

Because it is a derivative of 6-aminopenicillanic acid, DRY-CLOX has the potential for producing allergic reactions. Such reactions are rare; however, should they occur, the subject should be treated with antihistamines or pressor amines, such as epinephrine.

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

1Boddie RL, Nickerson SC and Sutherland SF.  New design of mastitis tubes reduces infections. Hoard's, 1989;134(13):579.

2Johnson AP, Godden SM, Royster E, et al.  Randomized noninferiority study evaluating the efficacy of 2 commercial dry cow mastitis formulations.  J Dairy Sci 2016;99:1-15.

3Makovec, JA and Ruegg, PL. Antimicrobial resistance of bacteria isolated from dairy cow milk samples submitted for bacterial culture: 8,905 samples (1994-2001). JAVMA, Vol. 222, No. 11, June 1, 2003. Pgs. 1582-1589.

Product Resources

Contact Information

  • Boehringer Ingelheim Vetmedica, Inc.

    Cattle Division

    3239 Satellite Blvd NW,
    Duluth, GA 64506

    • Phone 866-638-2226
    • Fax 816-326-9167
    • e-mail