Zactran® (gamithromycin) - Treat and control bovine respiratory disease in cattle.

The smart choice to combat BRD

Bovine Respiratory Disease, or BRD, is a serious condition for calves and is the number one cause of mortality in weaned calves. A single, economical administration of ZACTRAN provides effective 10-day BRD treatment and control.

Why should you use ZACTRAN?

Cattle producers share a little about their operations and why ZACTRAN is a smart choice for BRD treatment.

Product Description

ZACTRAN (gamithromycin) is an antibiotic that provides protection against the four major BRD causing pathogens.

  • ZACTRAN treats BRD associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in beef and non-lactating dairy cattle.
  • ZACTRAN controls respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with M. haemolytica and P. multocida.
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Features and Benefits

Strong Efficacy

  • ZACTRAN is labeled to treat all four of the major BRD-causing pathogens - Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis -in beef and non-lactating dairy cattle.

Speed to Action

  • Cattle treated with ZACTRAN responded within 24 hours; they had lower temperatures, were more alert and breathed easier.

Site of Infection

  • The pulmonary epithelial lining fluid (PELF) covers the surfaces in the lung and is the primary site of BRD. ZACTRAN travels with immune cells to the site of infection – the PELF. And it gets there in just 30 minutes.*

Staying Power

  • The animal’s immune system needs time to fight off BRD. ZACTRAN gives them that time with 10 days above MIC90 in the lung and PELF.*

Simple to Use

  • Accidental needle sticks can and do happen. You want a product that offers minimal risk while also minimizing the need to break up doses among multiple sites. It can be used with automatic syringes and offers a low-dose volume. It has excellent syringeability, even in freezing temperatures.

Saves Money

Economically managing BRD is critical to maintaining a profitable herd. When you compare costs per dose and add in all the other benefits, you’ll find ZACTRAN is a great value. Use our pricing calculator to compare costs with your current treatment.

*Clinical relevance has not been determined.

Presentation and Dosage

  • Administer ZACTRAN one time as a subcutaneous injection in the neck at
    6 mg/kg (2mL/110 lb) body weight (BW). If the total dose exceeds 10 mL, divide the dose so that no more than 10 mL is administered at each injection site.
  • ZACTRAN is available in 500, 250 and 100 mL sizes.
    The 500, 250 and 100 mL bottles contain sufficient solution to treat 50, 25 and 10 head of 550-lb. (250 kg) cattle, respectively.
  • ZACTRAN Dosing Chart

Safety Information

For use in cattle only. Do not treat cattle within 35 days of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle 20 months of age or older, or in calves to be processed for veal. The effects of ZACTRAN on bovine reproductive performance, pregnancy and lactation have not been determined.

Adverse Reactions: Transient animal discomfort and mild to moderate injection site swelling may be seen in cattle treated with ZACTRAN.
Storage: Store at or below 77 °F (25 °C) with excursions between
59-86 °F (15-30 °C). Use within 18 months of first puncture.

WARNING: FOR USE IN CATTLE ONLY. NOT FOR USE IN HUMANS. KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN. NOT FOR USE IN CHICKENS OR TURKEYS. The material safety data sheet (MSDS) contains more detailed occupational safety information. To contact the BIVI Veterinary Technical Services Team in case of questions or concerns, please call 1-(866)-638-2226 or e-mail

Product Resources

Contact Information

  • Boehringer Ingelheim Vetmedica, Inc.

    Cattle Division

    3239 Satellite Blvd NW,
    Duluth, GA 64506

    • Phone 866-638-2226
    • Fax 816-326-9167
    • e-mail