Equine Rhinopneumonitis + Influenza Vaccine

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For the vaccination of healthy, susceptible horses 6 months of age or older, including pregnant mares, as an aid in reduction of respiratory diseases caused by equine herpesvirus type 1 (EHV-1) and type 4 (EHV-4), and by equine influenza virus types A2 North American and A2 Eurasian.

CALVENZA family of vaccines:


This product has been tested under laboratory conditions and shown to meet all Federal standards for safety and efficacy in normal, healthy, immunocompetent animals. This level of performance may be affected by conditions such as stress, weather, nutrition, disease, parasitism, other treatments, individual idiosyncrasies or impaired immunological competency. These factors should be considered by the user when evaluating product performance or freedom from reactions.

Store at a temperature between 35° - 45° F (2° - 7° C). Protect from freezing. Shake well before using. Do not vaccinate within 21 days of slaughter.

CAUTION: Federal Law restricts this drug to use by or on the order of a licensed veterinarian.

  • Incorporates Florida sublineage Clade 1 (OH/03), Kentucky (KY/2/95), and Eurasian (NM/2/93) equine influenza strains
  • Unique EHV-1 equine respiratory origin isolate
  • Stimulates antibody to EHV-1 & EVH-4
  • Carbimmune adjuvant
  • Includes innovative pliable nasal applicator
  • Flexible dose administration using intramuscular or intranasal techniques
  • Minimal vaccine site reactions

Using aseptic technique inoculate horses IM with a 2 mL dose. Administer a second 2 mL dose IM in 3-4 weeks using a different injection site. Administer a third 2 mL dose in 3-4 weeks IM or IN.

  • Is there any equine rhinopneumonitis vaccine that protects against the neurological form of equine herpes?

    Currently there are no manufacturers that have a product indication offering protection against the neurological form of herpes.

  • Is CALVENZA efficacy and immunity well supported by studies and data?

    Calvenza has proven through multiple challenge studies and third party sources that there is a difference between vaccines.

    • Third party challenge study of three commercial killed vaccines1
    • Influenza North American and Eurasian A2 cross-protection study2
    • Influenza challenge study to demonstrate initial efficacy of two doses following two different administration protocols (IM/IM and IM/IN)2
    • Studies involving duration of immunity2
    • Two EHV-1 and two EHV-4 challenge studies3
  • What makes CALVENZA different from other influenza vaccines in the U.S.?

    CALVENZA incorporates a high antigen mass including flexible administration. These unique features coupled with an effective adjuvant along with a clade 1 (Ohio/03) equine influenza strain makes CALVENZA a very effective influenza Florida clade 1 vaccine.

  • Does CALVENZA EHV protect mares from EHV-1 abortion?

    CALVENZA has been proven safe for use in pregnant mares and is labeled accordingly. The use of CALVENZA for the aid in prevention of abortion is considered off-label use of the vaccine.

  • Will I experience site reactions with CALVENZA?

    Field safety trials, as well as feedback from clinical usage, indicate that a very low incidence of site reactions can be expected when CALVENZA is administered I.M.

  • Why were six and twelve month duration of immunity studies performed on the EIV fraction of CALVENZA?

    Boehringer Ingelheim Vetmedica, Inc., is a global manufacturer of veterinary products. CALVENZA was developed to be a superior vaccine for use by veterinarians in the United States and other countries. Some of these countries require a higher standard of performance to achieve governmental approval.

  • Aren't all carbomer-based adjuvant systems the same?

    No. Studies presented at the 2003 annual AAEP meeting clearly showed that vaccines incorporating properly formulated carbomer-based adjuvant systems produced higher antibody titers than vaccines containing other adjuvant systems. If sufficient antigen mass is not present for the adjuvant to amplify, the immune response and overall vaccine performance will be compromised no matter what strains or adjuvants are involved.

  • Does CALVENZA have supporting studies?

    Yes, among studies available Dr. Jenny Mumford and colleagues at the Animal Health Trust in Newmarket, England performed six and twelve month post vaccination challenge studies. The results of those studies demonstrated a significant reduction of severity and incidence of clinical signs, as well as quantity and duration of viral shedding in vaccinates versus non-vaccinated controls following challenge with virulent EIV.4

  • Does CALVENZA provide effective protection against rhinopneumonitis (herpesvirus)?

    Research leading to the original approval of CALVENZA had to prove to the satisfaction of USDA/APHIS that it provides protection against both EHV-1 and EHV-4. That is why CALVENZA is approved for both types of EHV and Boehringer Ingelheim Vetmedica, Inc., is allowed to state this on the label indications. All four EHV challenge studies demonstrated the ability of CALVENZA to reduce the signs of clinical disease and virus shedding in vaccinated horses following challenge as compared to non-vaccinated control horses.4 CALVENZA clearly demonstrated effective cross-protection against EHV-4 based on challenge.3


1 Townsend, H.G., et al. 49th Annual Convention of the American Association of Equine Practitioners, 2003 Proceedings. 
2 The Animal Health Trust, Newmarket, Suffolk England CB8 7UU 
3 Summit Research, Inc.
4Data on file.

Technical Assistance

  • Boehringer Ingelheim Vetmedica, Inc.

    Equine Division

    3902 Gene Field Road
    St. Joseph, Missouri 64506

    • Phone 866-638-2226
    • Fax 816-676-4326